“Our imaging work is mainly chemiluminescent blots of proteins associated with inflammatory diseases and is done by PhD and post-doctoral scientists, as well as students on our Masters’ course in Applied Biosciences. We were using ECL/X-ray film for this, but it was costly, required a darkroom and was difficult to obtain good quantitative results, which is why we assessed automated imagers.”

We decided to purchase a G:BOX Chemi XRQ because the imaging box is easy to upgrade and Syngene staff are more knowledgeable when we ask technical questions. Our G:BOX Chemi XRQ is now in regular use because it is simple for everyone to set up and produces good quality images. We are pleased we chose the G:BOX Chemi XRQ imager for our lab.”

Dr Grisha Pirianov, Senior Lecturer in Biomedical Sciences, Anglia Ruskin University, Cambridge, UK

“We are a department of 70 scientists mainly investigating breast cancer. Recently, we moved laboratory to a space which hadn’t got a darkroom and could no longer develop X-ray films of our chemiluminescent blots. We decided the time was right to move to digitising our imaging and reviewed systems from three different suppliers.”

“We installed the G:BOX Chemi XX6 in January 2017 because the system produces high quality images in a broad range of applications. We are very pleased with the G:BOX Chemi XX6 as it is simple to use and allows us to have a higher throughput of results compared to using X-ray film. We also like the fact that the system is easy to upgrade for different types of imaging.”

Laboratory Manager, Research Oncology, London University, London, UK

“We work with clinical diagnostic vaccines and after vaccination we have to image which proteins are being expressed by neutrophils and leukocytes on chemi labelled Western blots. This is time consuming to do manually using X-ray film and is why we needed an automated analyser in our laboratory.”

“Several scientists from other laboratories all recommended Syngene imagers for performance and quality. In 2015, we purchased a Syngene system without reviewing any others. My colleague and I have found our Syngene system is easy to use and has helped us obtain our Western blot results very rapidly.”

Pharmacist, Major Spanish Hospital, Spain

We are analysing chemiluminescent Western blots to look for expression of thrombospondin proteins. These can form oligomers which are larger than 200 kDa but can have low expression so it is very difficult using chemiluminescent blots and X-ray film to get the exposure just right to detect these proteins.

In 2017, we decided to install the Syngene G:BOX Chemi XRQ because this system can accurately image large gels and blots with ease. Using the G:BOX Chemi XRQ we can leave the system capturing multiple images and exposures and can always detect our proteins quantitatively even when the signal is faint, avoiding the risk of over-exposure. This means we can analyse our chemi blots more easily and have much more confidence in our results.

Dr Andrew Hellewell, Research Associate, School of Biochemistry, University of Bristol, UK

“We are analysing chemiluminescent Western blots to look for expression of proteins involved in neurodegenerative diseases. We were spending a huge amount of time using X-Ray film to visualize our Western blots. This was difficult, as well as time consuming.”

“We chose to upgrade from our old Syngene gel doc, which we have used for many years but couldn’t analyse Western blots on, to the newer G:BOX Chemi XX6 imaging system in 2016. Now 10 scientists regularly use the G:BOX Chemi XX6 to detect their chemiluminescent proteins and we may in future use the system for fluorescent Western blots too. We all like the G:BOX Chemi XX6 because the software is easy to use and we can obtain our results quickly.”

Laboratory Manager, Leading German University

“We are studying the changes that occur following exposure to stressors in non-coding RNAs in the model Gram positive bacteria, Bacillus subtilis. This may identify potential genetic targets, which could help in developing new anti-microbial therapies for drug-resistant bacteria. As part of this research we need an imager that can analyse chemi labelled Northern and Western blots, as well as image 25 cm plates of fluorescent protein expressing E. coli and B. subtilis colonies.”

“When we assessed the available image analysers, we found that the G:BOX Chemi XX6 is the only one with the flexibility to perform all these tasks so the system sold itself really. Since we installed the G:BOX Chemi XX6 in 2015, the system has become a well-used workhorse and we have not yet found a fluorescence or chemi application the G:BOX Chemi XX6 cannot perform.”

Dr Emma Denham, University of Warwick, Coventry, UK