Friday 3rd February 2012

Top medical school uses InGenius gel doc system to pinpoint microorganisms associated with chronic digestive diseases

Syngene is delighted to announce its InGenius gel imaging system is being used by scientists at the University of Glasgow to determine the types of microorganisms associated with Crohn's Disease and Coeliac Disease.

Researchers in the School of Medicine at the University of Glasgow are using a Syngene InGenius gel doc system to visualise microbial DNA stained with SYBR® Green on Temporal Temperature Gradient Electrophoresis polyacrylamide gels. The information obtained is being used to determine which microflora are associated with Crohn's Disease and Coeliac Disease in children and could help to determine the most effective methods to treat and control these conditions.

Dr Konstantinos Gerasimidis, Lecturer in Clinical Nutrition at the School of Medicine, University of Glasgow commented: “We are looking for microbes in children suffering with digestive diseases and are trying to determine those most prevalent in their colonic samples. For that we use a variety of molecular microbiology techniques such as Temporal Temperature Gradient Electrophoresis Gels stained with SYBR Green Nucleic Acids Staining. We prefer to use SYBR Green for visualising the DNA, rather than Ethidium bromide because it is significantly more sensitive and less toxic.”

Dr Gerasimidis continued: “We decided to upgrade our gel doc to an InGenius system because we have found it is more sensitive than other imagers we looked at in the same price range. We can easily visualise our DNA so we’re pleased we chose an InGenius.”

Laura Sullivan, Syngene’s Divisional Manager, concluded: “Establishing the potential causes of chronic digestive diseases is critical research and we are excited to hear that the InGenius is playing a part in this. The results researchers at University of Glasgow are obtaining, demonstrate to molecular biologists looking for an inexpensive system to safely and accurately image their DNA, that all they need is an InGenius.”

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