Published articles

2007 and earlier

Sunday 1st July 2007

CCD based system detects proteins

CCD-based system offers rapid method for detecting glycosylated and non-glycosylated proteins. This article appeared in Labmate UK/Ireland.

Thursday 1st March 2007

Scanning PACE gels with a CCD-based imager

Using a CCD-based imager to scan PACE gels provides a quick and sensitive method of analysis. This article appeared in International Labmate.

Thursday 1st March 2007

Imaging fluorescently stained DNA with CCD technology

Imaging fluorescent dyes with high sensitivity and short integration times is possible with CCD-based systems, which have a high performance camera capable of detecting a wide range of emission wavelengths. This article appeared in Biotechniques.

Wednesday 1st November 2006

CCD technology compared with laser-based scanning for analysing fluorescently labelled proteins

CCD based systems such as Dyversity are becoming the method of choice in order to produce accurate images of fluorescently labelled proteins in large gels or to rapidly detect low abundance differential protein expression in DIGE gel images where proteins may be labelled with up to three different Cy dyes. This article appeared in Biotechnology International.

Friday 29th September 2006

Proteomics: challenges and emerging technologies, EuroSciCon

This meeting highlighted some of the new approaches for capturing a large portion of the expressed proteome.

Saturday 1st July 2006

A new method for rapidly visualising multiple different proteins on Western blots

We describe here how the use of Qdot-labelled secondary antibodies coupled with a G:BOX Chemi CCD-based image analyser can be used to detect and produce an image of three different types of protein on one blot.

Friday 27th May 2005

Imaging fluorescent proteomics dyes - an inexpensive method of detection and analysis

This article describes how CCD-based technology can be used to detect the most popular fluorescent and visible protein dyes and the levels of sensitivity that this type of system can achieve.

Sunday 1st February 2004

Riboprobes imaging process brings benefit to spinal injuries research

With around 90,000 people worldwide iincurring a spinal cord injury each year, it is estimated that by 2005 the total world population living with such an injury will rise to over 2.5 million.

Friday 1st August 2003

Automated image analysis - improving accuracy and productivity in drug discovery

Pharmaceutical and biotechnology companies currently spend millions of pounds each working day on global research and development of new therapeutics for a range of diseases. Many of these firms have highly demanding research targets and aim to deliver as many as 15 candidate drugs annually. Nowhere is this felt more keenly than by those involved in genomics and proteomics research for drug discovery. Since these are relatively new fields, they still have to prove that they can help to generate good clinical candidates. Therefore, these groups are constantly trying to find ways of improving the speed and precision of their pre-clinical research processes in order to deliver promising results rapidly. This is where automation can help to improve accuracy and reduce substantial bottlenecks in areas such as quantification of nucleic acids and proteins, as well as counting recombinant clones.

Tuesday 1st January 2002

Identification of plants that cause subsidence damage using genetic data analysis

The seemingly arcane field of identifying tree roots has an important practical application. In assessing building damage caused by subsidence due to true roots, it is important for insurance and compensation purposes to be able to identify the offending trees from analysis of the roots. An EU-funded project is developing a genetic database of common trees and shrubs. Efficient use of this database requires sophisticated software systems for the storage and comparison of DNA gels.

Monday 1st October 2001

Automated imaging of Western blots and clonogenicity assays

One of the world's top five pharmaceutical companies, AstraZeneca, currently spends over £5 million each working day on global research and the development of new therapeutics for a range of diseases.

Sunday 1st October 2000

Chemiluminescent detection of nucleic acids

Chemiluminescence has been used for some years as an alternative to radioactive labelling for the detection of proteins and nucleic acids. Although chemiluminescent reagents have undergone many improvements in terms of sensitivity and speed since their first introduction, the disadvantages of film-based visualisation methods have restricted the wide-scale use of chemiluminescence

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